The trial was a multi-centre one with the purpose of evaluating whether there was a “significant” effect of the drug on the ability of patients to achieve and maintain a good erection, compared to placebo, with the addition of a “high-risk” dose of the drug. The study was approved by the Committee on Health and Human Services on 21 February 2006 and the Committee on Drug Use and Research at the University of Minnesota. The study was also approved by the Research Ethics Committee at the University of Minnesota. The trial was registered on the ClinicalTrials.gov as ‘C29-CT0796680.’
The study had two phases. In the first phase, the participants were given a 30-mg tablet of Cialis. In the second phase, they were given an initial dose of 20 mg of Cialis. The study was started in September 2004 and the trial continued for five years after that. The trial was completed in March 2008.
The primary endpoint was erectile function.
The primary efficacy measure was the ability to achieve and maintain a good erection. The primary outcome was the percentage of participants who had an erection at the time of the trial.
The second primary efficacy measure was the frequency of participants reporting difficulty achieving and maintaining a good erection. The study was conducted in the period from November 2004 to January 2009. During the first year, the number of participants who reported difficulty achieving and maintaining a good erection was approximately three. During the second year, the number of participants who reported a successful outcome was more than three.
The study was approved by the ClinicalTrials.gov website and the Research Ethics Committee at the University of Minnesota. The trial was also approved by the Research Ethics Committee at the University of Minnesota.
References1. Pfeifer H, Schoenmakers B, Schoenmakers B. The Effect of a High-Risk Dose of Viagra on the Ability of Healthy Volunteers to Achieve and maintain a Good Erection. JAMA. 1996; 283: 903-904.
2. Travison JL, Gagnon D, Travison J, Schoenmakers B, Gagnon K, Gagnon R, Travison L, Drosson D, et al. Effects of a High-Risk Dose of Viagra on the Ability of Healthy Volunteers to Achieve and maintain a Good Erection: A Population-based, Randomized, Placebo-Controlled, Follow-Up Study. 1996; 287: 1606-1608.
3. Lefèvre S, Montagu F, Dantovani E, Dantovani P, Mouton C, Béard P, Bouchard A, de Vaneau A, et al. Effect of a High-Risk Dose of Viagra on the Ability of Healthy Volunteers to Achieve and maintain a Good Erection: A Population-based, Randomized, Placebo-Controlled, Follow-Up Study. 1996; 287: 1604-1608.
4. Pfeifer H, Schoenmakers B, Schoenmakers B, Gagnon K, Gagnon R, Gagnon R, Travison L, Gagnon D, et al. 1996; 287: 1611-1614.
5. Haddad A, Khasrija A, Khasrija A. Erection after taking Viagra: A Randomized, Double-Blind, Placebo-Controlled Trial. 1998; 293: 1757-1764.
6. Mouton C, Gagnon D, Dantovani P, Béard P, de Vaneau A, et al. 1998; 295: 1718-1721.
7. Bouchard A, Gagnon R, Bouchard A, de Vaneau A, et al. 1998; 295: 1717-1720.
8.
Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.
Common side effects reported from Cialis use include:
More severe side effects include:
If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.
As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.
Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.
In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.
Read more about Cialis's effects and what you can expect during sex. can affect your quality of life.osaminymp=osamap=oostincomp/usynoost=usynoost/usynoostincomp/usynoost=usynoostin/usynoost=usynoostin/usynoostin/usynoost=usynoostin/usynoostin/usynoostin/usynoostin/usynoost=osamap=usynoostin=usynoostinRead more about how to take Cialis.As with all prescription medications, inform your doctor if you have or ever had any heart, blood, or nerve conditions. This could be a medical condition that make them more likely to need heart surgery or a conditions that make them more likely to experience chest pain during sex.
As with all prescription medications, inform your doctor of any medical condition you managing. This includes any stress, heart disease, or diabetes. Cialis can cause a number of these conditions, including generalized edema, hypertension, or congestive heart failure.
As with all prescription medications, be sure to have a medical condition history; any surgery or abnormally high or high blood pressure medication after sex
20mg daily dose onlineCialis works by increasing blood flow to the penis. This process involves factors like nitric oxide production, which activates the enzyme guanylate cyclase.
Cialis can also increase blood flow to the penis based on how much you take. This process is what keeps Cialis in the system, helping to achieve and maintain an erection.
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Quick OverviewAbout Cialis:Cialis is a widely recognized and trusted medication that contains the active ingredient Tadalafil. It is primarily prescribed to help men overcome the challenges of erectile dysfunction (ED), a common condition that can affect intimacy and overall well-being.
How Cialis Works:Cialis works by increasing blood flow to the penis, allowing men to achieve and sustain an erection when sexually stimulated. It is known for its long-lasting effectiveness, providing up to 36 hours of response to sexual stimulation.
Benefits of Cialis:
Usage and Dosage:Cialis should be taken as directed by a healthcare professional. The typical starting dose is 10mg, taken at least 30 minutes before anticipated sexual activity. The dosage may be adjusted based on individual response and tolerability.
Safety:Cialis is generally well-tolerated, but it's essential to follow your healthcare provider's recommendations. Discuss any medical conditions or medications you are taking with your doctor to ensure Cialis is safe and suitable for you.
Consultation:If you have questions or concerns about Cialis or its suitability for your condition, our licensed pharmacists and healthcare professionals are here to provide guidance and support.
Remember, Cialis is a prescription medication, and it's crucial to consult with a healthcare provider before starting any new medication. Our pharmacy is committed to helping you access the right treatment for your needs, promoting a healthier, happier, and more fulfilling life.
How to use:1 tablet before sexual activity once daily. The effect should give the ability for erection for 36 hours. Otherwise refer to physician's prescription
Precautions:Do not take another tablet except after 48 hours pass after the first tablet
Appetite controlFor the best experience on our store shelf, visit your store's Website and speak with a licensed pharmacist for personalized advice.
Take it with you by outlining specific factors that may affect the results:
1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).
2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.
3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.
Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:
Here are the key drug-food interactions:
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